Cefpodoxime proxetil
Cefpodoxime Proxetil (cefpodoxime proxetil) is a small molecule pharmaceutical. Cefpodoxime proxetil was first approved as Vantin on 1992-08-07. It is used to treat bacterial pneumonia, bacterial skin diseases, bronchitis, community-acquired infections, and cystitis amongst others in the USA.
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Cefpodoxime proxetil (discontinued: Banan, Cefpodoxime proxetil, Vantin)
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Cefpodoxime proxetil
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VANTIN | Pharmacia & Upjohn | N-050674 DISCN | 1992-08-07 | 2 products, RLD |
| VANTIN | Pharmacia & Upjohn | N-050675 DISCN | 1992-08-07 | 2 products, RLD |
| BANAN | Sankyo | N-050687 DISCN | 1992-08-07 | 2 products |
| BANAN | Sankyo | N-050688 DISCN | 1992-08-07 | 2 products |
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | 1 | 1 | 3 |
| Communicable diseases | D003141 | — | — | — | — | 1 | 1 | — | 2 |
| Otitis media | D010033 | EFO_0004992 | H66.9 | — | — | — | 1 | — | 1 |
| Otitis | D010031 | — | — | — | — | — | 1 | — | 1 |
| Otitis media with effusion | D010034 | EFO_0007415 | H65.3 | — | — | — | 1 | — | 1 |
| Pulmonary infarction | D054060 | EFO_1001408 | — | — | — | — | 1 | — | 1 |
| Soft tissue infections | D018461 | — | — | — | — | — | 1 | — | 1 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nephrolithiasis | D053040 | — | N20.0 | — | — | 1 | — | 1 | 2 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | 1 | — | 1 | 2 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | 1 | — | — | 1 |
| Rhinosinusitis | D000096825 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 1 | — | — | 1 | 2 |
| Anaphylaxis | D000707 | — | T88.6 | — | 1 | — | — | — | 1 |
| Drug hypersensitivity | D004342 | EFO_0009482 | T88.7 | — | 1 | — | — | — | 1 |
| Cephalosporin resistance | D018550 | — | Z16.19 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 3 | — | — | — | — | 3 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | — | — | — | — | 1 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | — | 2 | 2 |
| Microbiota | D064307 | — | — | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 1 | 1 |
| Blister | D001768 | — | — | — | — | — | — | 1 | 1 |
| Nut hypersensitivity | D021184 | EFO_1001066 | — | — | — | — | — | 1 | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | — | — | 1 | 1 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 1 | 1 |
| Aphasia | D001037 | HP_0002381 | R47.01 | — | — | — | — | 1 | 1 |
| Anomia | D000849 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cefpodoxime proxetil |
| INN | — |
| Description | Cefpodoxime is a third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis. It has a role as an antibacterial drug. It is a cephalosporin and a carboxylic acid. |
| Classification | Small molecule |
| Drug class | cephalosporins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COCC1=C(C(=O)OC(C)OC(=O)OC(C)C)N2C(=O)[C@@H](NC(=O)/C(=N\OC)c3csc(N)n3)[C@H]2SC1 |
Identifiers
| PDB | — |
| CAS-ID | 80210-62-4 |
| RxCUI | 20489 |
| ChEMBL ID | CHEMBL1201016 |
| ChEBI ID | 3505 |
| PubChem CID | 6335986 |
| DrugBank | DB01416 |
| UNII ID | — |
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Safety
Black-box Warning
Black-box warning for: 2-oak mix, red/white pollen 3-oak mix, black/blackjack/post pollen 3-ragweed mix, giant/short/western pollen 4-pine mix, austrian/loblolly/scotch/w..., Allspice almond apricot artichoke asparagus avocado banana barley grain bay leaf beet black olive black pepper blackberry blackeye pea blueberry br..., Almond apple apricot asparagus avocado bakers yeast banana basil bay leaf beet black pepper black walnut meat black-eyed pea blackberry blueberry b..., Pollens - trees, sycamore, american (eastern) platanus occidentallis animal allergens, ap cattle hair and dander animal allergens, ap dog hair and ...
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